Foxo1 ELISA Kit for Mouse(Mus musculus) | EIAab.comFoxo1 ELISA Kit for Mouse(Mus musculus)

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Foxo1 (Gene name),

Forkhead box protein O1 (Protein name ), FOXO1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Foxo1(Fkhr;Foxo1a);

Protein name:

Forkhead box protein O1;

Alternative:

Forkhead in rhabdomyosarcoma;Forkhead box protein O1A;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds to CDK1 and 14-3-3 proteins (By similarity). Interacts with LRPPRC. Interacts with SIRT1, and this interaction requires the presence of KRIT1. Interacts with NLK.

Function:

Triggers death of postmitotic neurons when phosphorylated by CDK1 (By similarity). Transcription factor which acts as a regulator of cell responses to oxidative stress. In the presence of KIRT1, mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence. Activates transcription of PMAIP1.

Subcellular Location:

Cytoplasm Nucleus Shuttles between cytoplasm and nucleus. Translocates to the nucleus upon oxidative stress induced phosphorylation at Ser-212 by STK4/MST1.

Protein Attributes:

Sequence length:

652

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

652:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9R1E0

UniGene:

Mm.29891

KEGG:

mmu:56458

Pfam:

PF00250

SMR:

Q9R1E0

STRING:

10090.ENSMUSP00000055308

Uniprot:

Q9R1E0

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ELISA Kit for Mouse Forkhead box protein O1

Cat.:

E0764m

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96T

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ELISA Kit for Mouse Forkhead box protein O1

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E0764h

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96T

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ELISA Kit for Mouse Forkhead box protein O1

Cat.:

E0764r

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ELISA Kit for Mouse Forkhead box protein O1

Cat.:

E0764p

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96T

ELISA Kit for Mouse Forkhead box protein O1

Cat.:

E0764b

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96T

CLIA Kit for Mouse Forkhead box protein O1

Cat.:

U0764p

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96T

CLIA Kit for Mouse Forkhead box protein O1

Cat.:

U0764m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Forkhead box protein O1

Cat.:

U0764b

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Forkhead box protein O1

Cat.:

U0764h

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Manual:

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96T

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CLIA Kit for Mouse Forkhead box protein O1

Cat.:

U0764r

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96T

Polyclonal Antibody for Mouse Forkhead box protein O1

Cat.:

P0764Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Forkhead box protein O1

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P0764Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Forkhead box protein O1

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P0764Rb-m

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40ug/0.2ml

Monoclonal Antibody for Mouse Forkhead box protein O1

Protein for Mouse Forkhead box protein O1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway."
Nakae J. , Park B.C. , Accili D.
J. Biol. Chem.274:15982-15985(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PHOSPHORYLATION AT THR-24; SER-253 AND SER-316;MUTAGENESIS OF THR-24; SER-253 AND SER-316
tissue: Liver.
2.

"The forkhead FKHR is involved in thymocyte proliferation."
Leenders H. , Benoist C. , Mathis D.
Submitted (2000-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
strain: NOD.
tissue: Thymus.
tissue: Vagina.
4.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction."
Puigserver P. , Rhee J. , Donovan J. , Walkey C.J. , Yoon J.C. , Oriente F. , Kitamura Y. , Altomonte J. , Dong H. , Accili D. , Spiegelman B.M.
Nature423:550-555(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPARGC1A;FUNCTION;PHOSPHORYLATION
6.

"Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice."
Furuyama T. , Kitayama K. , Shimoda Y. , Ogawa M. , Sone K. , Yoshida-Araki K. , Hisatsune H. , Nishikawa S. , Nakayama K. , Nakayama K. , Ikeda K. , Motoyama N. , Mori N.
J. Biol. Chem.279:34741-34749(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
7.

"Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity."
Daitoku H. , Hatta M. , Matsuzaki H. , Aratani S. , Ohshima T. , Miyagishi M. , Nakajima T. , Fukamizu A.
Proc. Natl. Acad. Sci. U.S.A.101:10042-10047(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-242; LYS-245 AND LYS-262;INTERACTION WITH SIRT1;DEACETYLATION;FUNCTION;MUTAGENESIS OF LYS-242; LYS-245 AND LYS-262
8.

"Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation."
Matsuzaki H. , Daitoku H. , Hatta M. , Aoyama H. , Yoshimochi K. , Fukamizu A.
Proc. Natl. Acad. Sci. U.S.A.102:11278-11283(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-242; LYS-245 AND LYS-262;PHOSPHORYLATION AT SER-253;DNA-BINDING;MUTAGENESIS OF LYS-242; LYS-245; SER-253 AND LYS-262
9.

"Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex."
Cooper M.P. , Qu L. , Rohas L.M. , Lin J. , Yang W. , Erdjument-Bromage H. , Tempst P. , Spiegelman B.M.
Genes Dev.20:2996-3009(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRPPRC
10.

"The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity."
Nakae J. , Cao Y. , Daitoku H. , Fukamizu A. , Ogawa W. , Yano Y. , Hayashi Y.
J. Clin. Invest.116:2473-2483(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIRT1;PHOSPHORYLATION;SUBCELLULAR LOCATION;FUNCTION;MUTAGENESIS OF THR-24; SER-253; SER-316; LEU-462 AND LEU-463
11.

"SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation."
Jing E. , Gesta S. , Kahn C.R.
Cell Metab.6:105-114(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION;DEACETYLATION BY SIRT2;FUNCTION IN INHIBITION OF ADIPOCYTE DIFFERENTIATION;INTERACTION WITH SIRT2
12.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
13.

"Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt."
Yamagata K. , Daitoku H. , Takahashi Y. , Namiki K. , Hisatake K. , Kako K. , Mukai H. , Kasuya Y. , Fukamizu A.
Mol. Cell32:221-231(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;SUBCELLULAR LOCATION;METHYLATION AT ARG-248 AND ARG-250;MUTAGENESIS OF ARG-29; ARG-147; ARG-154; ARG-248; ARG-250; ARG-311 AND ARG-313
14.

"SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma."
Wang F. , Tong Q.
Mol. Biol. Cell20:801-808(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION;DEACETYLATION BY SIRT2;INTERACTION WITH PPARG AND SIRT2;SUBCELLULAR LOCATION
15.

"Regulation of FOXO1 by TAK1-Nemo-like kinase pathway."
Kim S. , Kim Y. , Lee J. , Chung J.
J. Biol. Chem.285:8122-8129(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NLK;SUBCELLULAR LOCATION;PHOSPHORYLATION BY NLK;MUTAGENESIS OF SER-284; SER-295; SER-326; SER-380; SER-391; THR-399; SER-413 AND SER-415
16.

"Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization."
Qiang L. , Banks A.S. , Accili D.
J. Biol. Chem.285:27396-27401(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-24 AND SER-253;ACETYLATION;SUBCELLULAR LOCATION;FUNCTION;MUTAGENESIS OF THR-24; LYS-219; LYS-242; LYS-245; SER-253; LYS-259; LYS-262; LYS-271 AND LYS-291
17.

"Serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates adipocyte differentiation via forkhead box O1."
Di Pietro N. , Panel V. , Hayes S. , Bagattin A. , Meruvu S. , Pandolfi A. , Hugendubler L. , Fejes-Toth G. , Naray-Fejes-Toth A. , Mueller E.
Mol. Endocrinol.24:370-380(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-24; SER-253 AND SER-319 BY SGK1;SUBCELLULAR LOCATION
18.

"KRIT1 regulates the homeostasis of intracellular reactive oxygen species."
Goitre L. , Balzac F. , Degani S. , Degan P. , Marchi S. , Pinton P. , Retta S.F.
PLoS ONE5:E11786-E11786(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;INTERACTION WITH SIRT1;INDUCTION
19.

"FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide."
Hughes K.J. , Meares G.P. , Hansen P.A. , Corbett J.A.
J. Biol. Chem.286:8338-8348(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;ACETYLATION;RESPONSE TO NITRIC OXIDE
20.

"Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6)."
Meur G. , Qian Q. , da Silva Xavier G. , Pullen T.J. , Tsuboi T. , McKinnon C. , Fletcher L. , Tavare J.M. , Hughes S. , Johnson P. , Rutter G.A.
J. Biol. Chem.286:13647-13656(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION;DNA-BINDING
21.

"Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts."
Yang S. , Xu H. , Yu S. , Cao H. , Fan J. , Ge C. , Fransceschi R.T. , Dong H.H. , Xiao G.
J. Biol. Chem.286:19149-19158(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RUNX2;FUNCTION
22.

"The B55alpha-containing PP2A holoenzyme dephosphorylates FOXO1 in islet beta-cells under oxidative stress."
Yan L. , Guo S. , Brault M. , Harmon J. , Robertson R.P. , Hamid R. , Stein R. , Yang E.
Biochem. J.444:239-247(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERISTICS OF AN ANIMAL MODEL OF DIABETES MELLITUS TYPE 2;FUNCTION;DEPHOSPHORYLATION AT THR-24 AND SER-253;INTERACTION WITH PPP2R1A
23.

"Novel repressor regulates insulin sensitivity through interaction with Foxo1."
Nakae J. , Cao Y. , Hakuno F. , Takemori H. , Kawano Y. , Sekioka R. , Abe T. , Kiyonari H. , Tanaka T. , Sakai J. , Takahashi S. , Itoh H.
EMBO J.31:2275-2295(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A TRANSCRIPTIONAL ACTIVATOR;INTERACTION WITH FCOR AND SIRT1;TISSUE SPECIFICITY;MUTAGENESIS OF LYS-242; LYS-245; LYS-259; LYS-262; LYS-271 AND LYS-291
24.

"FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis."
Kode A. , Mosialou I. , Silva B.C. , Joshi S. , Ferron M. , Rached M.T. , Kousteni S.
J. Biol. Chem.287:8757-8768(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION;INTERACTION WITH ATF4;FUNCTION

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